with great sadness 意味

• 悲痛｛ひつう｝な面持ち｛おももち｝で
  He told me with great sadness that his wife had died of cancer. 彼は悲痛な面持ちで自分の妻ががんで亡くなったことを語った
  

例文

1. and it filled this old imam , it filled him with great sadness .
   この年老いたイマームは悲しみに暮れました
2. and so , it is with great sadness we must say goodbye to nan who fell in the tub .
   とても悲しい事に バスで無くなったナンに お別れしなければならない